Bivariate analysis of subgroups revealed no correlation between ceramide-Ab or S1P levels and the presence of comorbidities, including coronary heart disease (ceramide-Ab, p = 0.59; S1P, p = 0.31), diabetes (ceramide-Ab, p = 0.36; S1P, p = 0.69), and hypertension (ceramide-Ab, p = 0.45; S1P, p = 0.88). Here, MBTPS1 is linked to hypertensive disorder.