TP53 and neoplasm: Excluding chaotic because of the small sample size, the 60-gene signature confirmed mortality risk prediction after adjusting for age, sex and tumor stage (c-index=0.682), with steady significantly associated with prolonged survival overall (Fig. 6A, HR=0.32, 95% CI=0.12–0.87, p=0.026) and within TP53-wt tumors (Fig. 6B).