A statistically significant difference in methylation levels was observed when comparing IPF samples vs. NFLT (Mann Whitney test, p = 0.04, Supplementary Table S2) and SPARC hypermethylation was observed in IPF samples ranging from 0 to 119 (Mean 5,6 ± 18,1, interquartile range, IQR 0–5,8). The gene discussed is SPARC; the disease is idiopathic pulmonary fibrosis.