Future studies employing high-resolution approaches, as well as pyrosequencing or targeted bisulfite sequencing, are warranted to accurately map methylation at individual CpG sites within the SPARC promoter, overcoming the limitations of QMSP (Consortium, 2016), and to elucidate their regulatory role in transcriptional silencing mechanisms associated with IPF. This evidence concerns the gene SPARC and idiopathic pulmonary fibrosis.