Defective differentiation capacity in DMD-MuSCs occurs via alteration of cellular pathways, including reduced signal transducer and activator of transcription 3 (STAT3) (Liu Y. et al., 2025) and phosphatidylinositol-3 kinase (PI3K)/Akt signaling (Yazid and Hung-Chih, 2021). Here, STAT3 is linked to Duchenne muscular dystrophy.