CENPB and systemic sclerosis: In more recent medical literature, anti-endothelial antibodies, including CENP-B, have been described as potential functional antibodies in SSc, associated with vascular involvement (digital vasculopathy) by activating endothelial cell modulation of fibroblast dysfunction and antibody-dependent cell-mediated cytotoxicity (ADCC) with endothelial apoptosis [2].