5-HT2A: 5-hydroxytryptamine receptor 2A; NMDA: N-methyl-D-aspartate; HR: Heart rate; BP: Blood pressure; ADNP: Activity-dependent neuroprotector homeobox; GAD: Generalized anxiety disorder; MAP: Mean arterial pressure; SUD: Substance use disorder. This evidence concerns the gene ADNP and generalized anxiety disorder.