CRP and Sepsis: The clinical question of this systematic review utilized the PICO format: P (patient, population, problem) - neonates with sepsis, I (intervention or exposure) -use of C-reactive protein in the detection of neonatal sepsis, C (comparison) - use of procalcitonin in the detection of neonatal sepsis and O (outcome)- early diagnosis (within 48 hours) of neonatal sepsis.