No single ideal biomarker was found. CRP described as a specific for neonatal sepsis with normal levels ruling it out and sensitivity increasing with serial values. Benefit of PCT in the diagnosis of EOS is its earlier rise and rise being independent of gestational age. Limitations of CRP in diagnosing EOS include its slow rise (late biomarker), long half-life and rise in non-infectious conditions. PCT limitations include rise in non-infectious conditions (like CRP) and inability for sole use to diagnose neonatal sepsis. Improvements include the use of a lower cut-off value. This evidence concerns the gene CRP and Neonatal sepsis.