CRP performed better but need to consider its inclusion in the definition of uncertain and probable sepsis cases. CRP had a physiological rise. PCT limitations include its cost and kinetics (which require nomogram use). Normal CRP and PCT, within 36h starting empirical antibiotic initiation confidently support their discontinuation. Benefit seen in combining PCT and CRP.  Difficulty of culture-negative sepsis management discussed. Study limitations include its design as a secondary analysis (potential bias introduction) and small sample size of proven sepsis cases. Here, CALCA is linked to Sepsis.