In conclusion, PCT demonstrates superior diagnostic potential and utility in guiding antibiotic therapy compared to CRP for early diagnosis of neonatal sepsis, especially when used in combination with other biomarkers. As part of our review, we noted the absence of procalcitonin in current international neonatal sepsis guidelines, and we have proposed a flowchart to guide its potential integration into clinical practice. Here, CALCA is linked to Neonatal sepsis.