Together with Na+-dependent pH regulatory proteins, Na + transporters are generally upregulated in HCC and cancer in general (i.e., Na+/Ca2+ exchanger, Na+/K+/2Cl- and Na+/glucose co-transporters) or are expressed in HCC but not in the corresponding un-transformed tissue (acid sensitive ion channels). Here, SLC8A1 is linked to hepatocellular carcinoma.