Meanwhile, Chen et al. used PF to treat the withdrawal hormone simulated pregnancy (HSP) in a Postpartum depression (PPD) rat model and found that PF improved PPD symptoms by promoting the activation of the transporter TspO and BDNF/mTOR pathways in PPD rats, proving that PF may be an effective anti-PPD and anti-depression drug (Chen J. et al., 2022). This evidence concerns the gene BDNF and depressive disorder.