CREB1 and medical procedure: PF reversed the significant reduction of p-CaMKII and p-CREB and regulated the expression of downstream proteins in the Middle Cerebral Artery Occlusion(MCAO) model and N-methyl-D-aspartic acid receptor(NMDA) induced excitatory toxicity model of primary hippocampal neurons, including Bax, Bcl2, Bad, and Caspase3, along the Ca2+/CaMKI/CREB signaling pathway (Zhang et al., 2017).