SNS can activate the CaSR-PKC-ERK signaling pathway, upregulate the expression of serotonin 1α receptors (5-HT1α), phosphorylated cAMP response element-binding protein (p-CREB), and BDNF in the hippocampus, thereby alleviating depressive and anxious behaviors in MS rats (Shen et al., 2020; Cao et al., 2019). The gene discussed is HTR1A; the disease is myeloid sarcoma.