SIRT1 and Cognitive impairment: NOR and FCT tests showed that Sirt1 overexpression ameliorated cognitive impairment in GBP-treated mice (Figures 6B–G, GBP groups: eGFP vs. Sirt1, **p < 0.01, Supplementary Figures S2A,C, AAV-eGPF/saline and AAV-Sirt1/GBP: pre-context vs. pre-tone, *p < 0.05).