MAPT and early-onset autosomal dominant Alzheimer disease: Among five p-tau proteins examined, the levels of p-tau (S416) and p-tau (S262) were elevated in the brain of GBP-treated aged mice, both phosphorylation sites are associated with pathophysiology of Alzheimer’s disease (AD) (Hasegawa et al., 1992; Drewes et al., 1995; Seward et al., 2013; Amar et al., 2017).