SIRT3 and Cognitive impairment: Curcumin is a bioactive polyphenolic compound extracted from the rhizome of Curcuma Longa L. It could significantly improve cognitive impairment in APPTG mice and alleviate neuronal metabolic dysfunction induced by Aβ42 though regulating the NAD+/NADH ratio and activating SIRT3 (Zia et al., 2021; Liu M. et al., 2021).