HMOX1 and Sepsis: This study elucidates that lipopolysaccharide‐binding protein (LBP) ameliorates sepsis‐induced myocardial injury by activating the nuclear factor erythroid 2‐related factor 2/heme oxygenase‐1 (NRF2/HO‐1) signaling pathway, thereby suppressing lipid peroxidation and ferroptosis.