We selected independent genetic variants strongly associated with five lifestyle factors (lifetime smoking index, smoking initiation, alcohol consumption, coffee intake, and vigorous physical activity) and ten metabolic traits (body mass index (BMI), waist‐hip ratio, type 2 diabetes, systolic/diastolic blood pressure, high/low‐density lipoprotein, apolipoprotein A‐1/B, and triglycerides) as instrumental variables through rigorous quality control (R2 < 0.001, p ≤ 5 × 10−8). The gene discussed is APOA1; the disease is type 2 diabetes mellitus.