These findings align with the large-scale prospective study by Elkrief et al. (24), which reported that combining hepatocyte-derived biomarkers such as keratin 18 and extracellular vesicles with the MELD score significantly improved prediction of liver-related events in patients with compensated alcoholic cirrhosis (HR for EVs = 5.09; for K18 = 1.77) compared to using MELD alone. This evidence concerns the gene KRT18 and alcoholic liver cirrhosis.