Its application significantly increased the expression of various antimicrobial peptides (S100 Calcium Binding Protein A8 (S100A8), S100 Calcium Binding Protein A9 (S100A9), CCL20, elafin, lipocalin 2, human β-defensin 2) and innate immune genes (IL-6, IL-8, and IL-1β) in the skin of patients with AD. Here, S100A8 is linked to Alzheimer disease.