Mo et al., demonstrated culturing CAR-engineered Vδ2 T cells in human platelet lysate, which contains TGF-β (84), supplemented media reduces cellular senescence and apoptosis, ultimately boosting in vivo anti-tumor activity against B-cell acute lymphoblastic leukemia (B-ALL) (34). The gene discussed is TGFB1; the disease is acute lymphoblastic leukemia.