Patient characteristics were similar between the two cohorts, including gender, age, concurrent Epstein-Barr virus, HIV transmission route, cART therapy, years of HIV infection prior to lymphoma, ECOG-PS, WBC, PLT, CD4/CD8, elevated serum lactate dehydrogenase (LDH), elevated serum β2-microglobulin (β2-MG), Ann Arbor stage, extra-nodal involvement, bone marrow involvement, and chemotherapy regimen (p>0.05). The gene discussed is CD4; the disease is lymphoma.