Comparative analysis of immune parameters revealed that HIV-HL patients had significantly reduced median values in multiple hematologic and immunologic markers, including CD4+ cells (110 cells/μL vs. 483 cells/μL; p<0.001) and lower CD4/CD8 ratio (31.6% vs. 16.2%, p<0.001). This evidence concerns the gene CD4 and Hodgkins lymphoma.