demonstrated that the expression of colorectal cancer-related genes (LCN2 and DUOX2) is closely related to the abundance of colorectal cancer related bacteria (Ruminococcaceae and Veillonella) through the combined analysis of RNA-seq and 16S rRNA, indicating the potential role of host gene-microbe interactions in the pathogenesis of colorectal cancer in cystic fibrosis (27). The gene discussed is LCN2; the disease is colorectal cancer.