FLG and Alzheimer disease: Notably, a Taiwanese cohort study involving 12,022 AA patients and 40,307 AD patients (8), not only reiterated the bidirectional increased risk between AD and AA, but also demonstrated that AD patients carrying Filaggrin gene (FLG) mutations exhibited exacerbated AA manifestations compared to those without genetic predisposition, further strengthening the further reinforcing the complex and multidimensional association between AD and AA.