Notably, STAT6 protein plays a central regulatory role in this signaling pathway, which not only upregulates the expression of the Th2-specific transcription factor GATA3 and regulates T cell proliferation and Th2 cell differentiation, but also promotes the conversion of immunoglobulin classes to IgE and IgG1 in B cells (59), which correlates with the fact that multiple STAT6 polymorphisms are associated with high levels of IgE and an increased AD susceptibility is closely associated with increased susceptibility (60). This evidence concerns the gene STAT6 and Alzheimer disease.