Specifically, the average tumor size was 3,256.5 mm3 in the CpG group, while it was reduced to 1,649.7 mm3 in the TOP2A group (p<0.01), 2,242.5 mm3 in the IGF-1R group, 1,703.2 mm3 in the HIF-1α group (p < 0.05), and down to 361.7 mm3 in the TNBCvax group (p<0.0001). This evidence concerns the gene HIF1A and neoplasm.