Specifically, the average tumor weight at the experimental endpoint was 1.96 g in the CpG control group, whereas it was reduced to 1.14 g in the TOP2A group, 1.58 g in the IGF-1R group, 1.47 g in the HIF-1α group, and 0.32 g in the TNBCvax group (p<0.001). This evidence concerns the gene HIF1A and neoplasm.