HIF1A and neoplasm: At the experimental endpoint of 57 days, the average tumor size in the CpG group was 978.2 mm3, whereas it was significantly reduced to 318.1 mm3 in the TOP2A group (p<0.0001), 430.9 mm3 in the IGF-1R group (p<0.0001), 315.8 mm3 in the HIF-1α group (p<0.0001), and 220.8 mm3 in the TNBCvax group (p<0.0001).