TG and autoimmune thyroid disease: This implies its potential use as a functional biomarker, particularly in regions with low iodine levels.8,9 Venables et al suggested the use of Tg as a sensitive indicator for evaluating thyroid function, particularly in situations involving decreased or elevated levels of iodine.10 Research on thyroid autoimmunity and its effects on pregnancy outcomes has highlighted the importance of Tg, further emphasizing its role in assessing thyroid function during pregnancy.