(2023) investigated the role of high mobility group box-1 protein (HMGB1) and soluble receptor for advanced glycation end-products (sRAGE) in the context of ECT, analyzing 25 MDD patients (median age [range]: 54.2 [48–63]; 56% female) and 25 healthy controls (median age [range]: 53.2 [47–61]; 56% female). The gene discussed is HMGB1; the disease is major depressive disorder.