For the European Group for Study of Insulin Resistance (EGIR) a diagnosis of MetS is made when there is elevated plasma insulin (>75th percentile) plus two other factors from among the following: Abdominal obesity: waist circumference (WC) ≥ 94 cm in men and ≥80 cm in women, hypertension: ≥140/90 mm Hg or on antihypertensive treatment, elevated triglycerides (≥150 mg/dL) and/or reduced HDL-C (<39 mg/dl for both men and women), elevated plasma glucose: impaired fasting glucose (IFG) or IGT, but no diabetes (47). The gene discussed is INS; the disease is Abdominal obesity.