Table 4 presents the results of the bidirectional mediation model, analyzing the interactive mechanism between TyG-BMI and depression on stroke risk (adjusting for confounding factors such as age, gender, marital status, education level, smoking, alcohol consumption, hypertension, diabetes, Waist, SBP, DBP, Glu, HDL, LDL, TC, TG and CRP). This evidence concerns the gene CRP and major depressive disorder.