A study on colon cancer cell lines that carry wild-type p53 (wtp53) or mutant p53 (mutp53) shows that curcumin alters the methylation patterns and expression levels of various methyltransferases in colon cancer cells with both wild-type p53 (wtp53) and mutant p53 (mutp53) (20). Here, TP53 is linked to colonic neoplasm.