PRDX1 and metabolic dysfunction-associated steatohepatitis: In non-alcoholic steatohepatitis (NASH), the overall peroxiredoxin activity of peroxiredoxin reductase (PRDX) in the liver is significantly decreased, which is further exacerbated by palmitic acid (PA) by directly binding to PRDX1 and inhibiting its peroxidase activity (62).