This lipotoxicity notably exacerbates hepatic IR, thereby perpetuating a detrimental cycle of “lipid accumulation-IR.” Conversely, in this group, serum IL-27 levels were notably higher and showed a negative correlation with fasting blood glucose (FBG), the homeostasis model evaluation for insulin resistance, TG levels, and both subcutaneous and visceral fat content (126). The gene discussed is IL27; the disease is Insulin resistance.