EMX2 exerts tumor-suppressive functions in TNBC by directly binding to the E-cadherin promoter to maintain the epithelial phenotype and by repressing the expression of key EMT transcription factors such as TWIST1, thereby inhibiting EMT and cancer stem cell (CSC) properties (Wang et al., 2019; Zhang et al., 2023). The gene discussed is TWIST1; the disease is cancer.