Overexpression or mutation of Gα13/13 or Gα12/13‐linked GPCRs, such as thromboxane A2 receptor TA2R (TBXA2R) or protease‐activated receptor 1 (PAR1) (F2R), can induce aberrant Gα12/13‐driven signaling, which is transformative and dramatically increases the possibility for invasion of several cancer types [175, 186, 187, 188]. This evidence concerns the gene MARK2 and cancer.