Through TCGA, the most common mutations in GNAS are found in endometrial carcinomas (7.3%), colorectal malignancies (4.7%), adrenocortical carcinomas (5.5%), stomach adenocarcinomas (5.7%), esophageal carcinomas (4.9%), pancreatic adenocarcinomas (5.6%), and ulcerative carcinomas (5.7%). The gene discussed is GNAS; the disease is pancreatic adenocarcinoma.