Previous research has established that HMGB1 plays a pivotal role in the initiation process, advancement, and therapeutic management of numerous cancer types, including colorectal cancer (46), pancreatic cancer (47), non-small cell lung carcinoma (NSCLC) (48), melanoma (49), ovarian cancer (50), breast cancer (51), and hepatocellular carcinoma (52). This evidence concerns the gene HMGB1 and non-small cell lung carcinoma.