Hypoxia is one of the hallmarks of a variety of solid tumors, and it promotes tumor invasion into surrounding tissues and even distant metastasis by inducing the hypoxia-inducible factor (HIF) family of transcription factors, This pathway activates the expression of multiple growth factors, including vascular endothelial growth factor (VEGF), in addition to angiopoietin 2 (Ang-2) and fibroblast growth factor (FGF) (60). The gene discussed is VEGFA; the disease is neoplasm.