In the study of immune evasion in renal cell carcinoma, it was found that HMGB1 did not directly affect adaptive immunity, but promoted the proliferation of myeloid-derived suppressor cells (MDSCs) by interfering with the differentiation of dendritic cells, inhibiting the role of immunotherapy in renal cell carcinoma (84). Here, HMGB1 is linked to hereditary clear cell renal cell carcinoma.