In the study of immune evasion in renal cell carcinoma, it was found that HMGB1 did not directly affect adaptive immunity, but promoted the proliferation of myeloid-derived suppressor cells (MDSCs) by interfering with the differentiation of dendritic cells, inhibiting the role of immunotherapy in renal cell carcinoma (84). The gene discussed is HMGB1; the disease is renal cell carcinoma.