By blocking the Janus kinase 2 (JAK2)/STAT3 signaling pathway through direct interaction with JAK2, baicalein (7.5-30μM) dose-dependently reduced the expression levels of GPX4, a key regulator of ferroptosis, in HCT116 and DLD1 cells, ultimately causing ferroptosis in CRC cells, according to Lai, Zhao, et al. The gene discussed is STAT3; the disease is colorectal carcinoma.