Notably, this case’s Syn positivity hints at potential neuroendocrine features, and GATA3-driven regulation of neuroendocrine transcription factors (e.g., ASCL1/NEUROD1) may interact with GATA5/6, possibly influencing the Hedgehog/Wnt signaling pathways that promote mucin secretion and tumor progression (27, 31). This evidence concerns the gene ASCL1 and neoplasm.