IFITM3 and acute myeloid leukemia: However, to further elucidate the role of IFITM3 in tumorigenesis and metabolism, additional studies are needed to investigate how IFITM3, as a key scaffold protein of the PI3K-Akt signaling pathway, enhances PI3K signaling by binding to phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and its impact on AML progression25.