IFITM3 and acute myeloid leukemia: The interferon-induced transmembrane protein 3 (IFITM3), encoded on chromosome 11, is a key member of the IFITM family with roles in cell differentiation, apoptosis, inflammation, and immune modulation (5, 6).While IFITM3 overexpression has been implicated in the progression of multiple solid tumors, such as promoting proliferation, metastasis, invasion, and epithelial-mesenchymal transition (EMT) (7–9),its role in AML remains poorly understood.