Both in vitro and in vivo studies have demonstrated that astragaloside IV (75) and MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) (76) suppress HSCs activation and attenuate liver fibrosis by inhibiting the TGF-β1/Smad pathway through antioxidant stress mechanisms. Here, TGFB1 is linked to Hepatic fibrosis.