In the pathogenesis of pulmonary fibrosis, Forkhead box protein O3 (FOXO3) inhibits fibroblast activation and ECM deposition via its interaction with TGF-β1-induced Smad3, thereby attenuating idiopathic pulmonary fibrosis (IPF) (93, 99). The gene discussed is TGFB1; the disease is pulmonary fibrosis.