NFIB and pulmonary fibrosis: Moreover, research into miRNAs underscores the importance of this pathway: for example, miR-326-mediated overexpression of nuclear factor I-B (NFIB) inhibits TGF-β-induced EMT and reverses pulmonary fibrosis (100), while miR-486-5p alleviates fibrosis in radiation-induced lung injury (RILI) by suppressing Smad2 and activating Akt (101).