VEGFA and neoplasm: Effective coupling of capillary beds with tumor parenchyma demands not only structural fusion but also precise coordination of biochemical-biomechanical signaling networks, Gradients of vascular endothelial growth factor (VEGF)Spatiotemporal pericyte recruitment Hemodynamic Force Deficiency: Static culture systems fail to replicate the regulatory effects of hemodynamic shear stress on vascular maturation.