An intriguing example for our limited understanding of an NDD is presented by cases of Parkinson’s Disease associated with Parkin mutations: Lewy bodies, considered a hallmark of Parkinson’s, are round-to-elongated eosinophilic cytoplasmic inclusions, characterized by a dense central core composed by tightly packed α-synuclein filaments, and a surrounding pale rim with more loosely arranged α-synuclein. The gene discussed is PRKN; the disease is Parkinsonism.