Plasma levels of VWF were significantly associated with changes in MMSE (lower scores represent worse cognitive performance; Coefficients [95% CIs] = 0.204 [0.030, 0.378]; p value = 0.021; Figure 3A) and CDR-SB (higher scores represent worse cognitive performance; Coefficients [95% CIs] = −0.268 [−0.374, −0.163]; p value < 0.001; Figure 3B) over time among older adults without dementia, suggesting that lower levels plasma VWF were associated with a steeper rate of cognitive decline. This evidence concerns the gene VWF and dementia.