VWF and Mental deterioration: We observed that lower plasma VWF levels were associated with a faster rate of cognitive decline (MMSE: coefficient = 0.204, 95% CIs = [0.030, 0.378], p-value = 0.021; CDR-SB: coefficient = −0.268, 95% CIs = [−0.374, −0.163], p-value <0.001).