EDN1 and Insulin resistance: In the current study, we determined if female mice overexpressing the human ETB on adipocytes (adETBOX) have impaired insulin resistance and dyslipidemia after 10 weeks of HFD feeding, providing valuable insight into the role of ET‐1 and ETB receptors in adipose tissue and their contribution to the differential susceptibility of female mice to diet‐induced metabolic dysfunctions.