EDN1 and obesity due to melanocortin 4 receptor deficiency: Elevated levels of endothelin‐1 (ET‐1) are associated with obesity and insulin resistance in humans and increased in visceral adipose of obese mice fed a high‐fat diet (HFD) (Ferri et al., 1995; Ottosson‐Seeberger et al., 1997; Rivera‐Gonzalez et al., 2021).