Interestingly, unlike in conditions characterized by low‐grade inflammation such as obesity and type 2 diabetes [37, 38, 39], PPARγ activation in our model did not lead to a reduction in classical pro‐inflammatory cytokines This may be explained by the absence of low‐grade inflammation following DOXO treatment in our experimental setting. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.