Large‐scale fine mapping has localised T1D association signals to two distinct IL2RA regions spanning intron 1 and the 5′ promoter, and risk genotypes correlate with lower circulating soluble IL‐2RA levels, suggesting that impaired IL‐2 responsiveness predisposes to autoimmunity, for example, the two T1D‐GRS2 markers rs61839660 and rs41295121 in the IL2RA locus.68, 69. This evidence concerns the gene GORASP2 and type 1 diabetes mellitus.