Among the top 100 deregulated genes, Wnt-associated genes such as LGR5, DKK1, and NKD1, as well as the HB-related genes DUSP9, DLK1, PEG3, PEG10, IGF2BP1, and IGF2BP2 were consistently upregulated in tumor samples (Fig. 1C). The gene discussed is LGR5; the disease is neoplasm.