As shown in Fig. 7, for several genes, most notably CNOT7, GDI1 and SLC25A37, there are a subset of tumours that showed homozygous deletion and thus inhibition/suppression of CNOT8, GDI2 or SLC25A28, respectively, would be predicted to provoke cellular lethality/reduced cancer cell fitness. Here, CNOT8 is linked to neoplasm.