During the progression of osteoarthritis, down syndrome candidate region 1–1 (DSCR1-1) can inhibit chondrocyte apoptosis by regulating the cAMP-responsive element protein 1 (CREB1)/ALDH2/Wingless and int-1 (Wnt)/β-catenin axis [80]. The gene discussed is CREB1; the disease is osteoarthritis.