ANGPTL4 and Netherton syndrome: They found that lipid disorders and podocyte effacement were relieved in mice with the knocked-out ANGPTL-4 gene, with significantly lower proteinuria and substantially reduced total cholesterol and triglyceride levels as opposed to nephrotic mice with the gene, underlining the role of ANGPTL-4 in both the pathophysiology of NS and the associated hyperlipidemia.