SPP1 and Cerebral cortical atrophy: In the case of an inflammatory condition like MS, it might contain elements indicative of the type of underlying inflammation, such as: involvement of complement55,77; indicators of the stage of MS via analysis of microRNA and targeted proteomics78; cytokine profiles that predict prognosis or response to therapy79; a specific biomarker for MS such as CD13880; or a marker such as osteopontin, that can be correlated with the degree of disability or cortical atrophy.81