Furthermore, curcumin has been extensively studied for its interactions with TLRs/NF-κB signaling in various pathological conditions including inflammation [58], acute pancreatitis [59], and cerebral ischemia [60], the mechanistic roles of ar-turmerone in modulating this pathway, particularly in the context of AD, remain poorly understood. The gene discussed is NFKB1; the disease is Alzheimer disease.