Table 4 shows that, before targeted therapy, the CRP concentration (mean 7.05, SD 10.26 mg/L) of the group with no cognitive disorder was significantly lower than that of the group with cognitive disorder (mean 16.04, SD 19.88 mg/L), and there was a significant difference between the 2 groups (z=−2.175; P=.03). The gene discussed is CRP; the disease is Cognitive impairment.