IRF3, activated downstream of TLR3, plays a key role in PE by promoting excessive inflammation through interferon-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}$\beta $\end{document} production and contributing to endothelial dysfunction [65]. Here, IRF3 is linked to endothelial dysfunction.