CTCF and folate deficiency: R‐loops can serve as intermediates through Pol II stalling in DNA damage repair processes, and abnormal accumulation of R‐loops can impede replication fork progression.[8d] When considering that chromatin is organized into loops and self‐interacting units called TADs by cohesion and CTCF, how DSBs affect loop and TAD organization under folate deficiency remains unknown.