Mechanistically, circPVT1 promotes RCC progression through two distinct mechanisms: by encoding a novel 104‐amino acid peptide, cP104aa, via IRES‐dependent translation, which subsequently upregulates c‐MYC expression by binding to heterogeneous nuclear ribonucleoprotein K (HNRNPK), and by directly binding to EIF4A3 to increase c‐MYC expression. Here, EIF4A3 is linked to renal cell carcinoma.